1: in tetrahydrofuran T=-65 - 20°C; 5.16667 h; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C;

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in acetonitrile 70 h; Heating / reflux;

n-butyllithium in hexane; toluene T=-70 - -50°C; Product distribution / selectivity;

1: 2-bromo-5-fluoropyridine With isopropylmagnesium chloride in tetrahydrofuran; toluene T=25 - 30°C; 1 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; toluene T=5 - 10°C; 4 h; Product distribution / selectivity;