1-(4-甲氧基苯甲酰基)哌啶-4-酮合成路线 （共 5 条）
反应条件
pyridine
T=20°C; 18 h;
参考文献
Burns Barbier, Lindsay; Wang, Hoau-Yan; Lin, Nan-Horng; Blasko, Andrei
Patent: US2010/280057 A1, 2010 ;
Location in patent: Page/Page column 30-31 ;
US 20100280057 A1
反应条件
sulfuric acid in tetrahydrofuran
T=25°C; 20 h;
参考文献
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
反应条件
1: 92 percent / tetrahydrofuran / 1.5 h / 25 °C
2: 74 percent / 10percent aqueous H2SO4 / tetrahydrofuran / 20 h / 25 °C
View Scheme
参考文献
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
反应条件
1: 92 percent / tetrahydrofuran / 1.5 h / 25 °C
2: 74 percent / 10percent aqueous H2SO4 / tetrahydrofuran / 20 h / 25 °C
View Scheme
参考文献
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
反应条件
1: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux
2: 91 percent / toluene / 24 h / 120 °C
3: 97 percent / 1.0N aqueous NaOH / methanol; tetrahydrofuran / 10 h / 25 °C
4: 1) 1N aqueous KOH 2) oxalyl chloride / 1) MeOH, 25 deg C 2) dry benzene, ca.3h, 25 deg C
5: 76 percent / tetrahydrofuran / 1 h / -78 °C
6: 62 percent / m-CPBA / CH2Cl2 / 25 °C
7: 70 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
