2-(氮杂啶-1-基羰基)-5-氯吡嗪合成路线 （共 4 条）
反应条件
1: 5-chloro-pyrazine-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
2: trimethylene imine With triethylamine in dichloromethane
T=20°C; 72 h;
参考文献
AstraZeneca AB
Patent: US2008/171734 A1, 2008 ;
Location in patent: Page/Page column 44-45 ;
US 20080171734 A1
反应条件
triethylamine in dichloromethane
T=20°C; 72 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7041 A1, 2007 ;
Location in patent: Page/Page column 143 ;
WO 2007/007041 A1
反应条件
1: azetidine hydrochloride With triethylamine in dichloromethane
T=20 - 25°C; Inert atmosphere;
2: 5-chloro-pyrazine-2-carbonyl chloride in dichloromethane
T=-10 - -5°C; pH=> 7;
参考文献
AstraZeneca AB
Patent: US2010/210841 A1, 2010 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: 5-chloro-pyrazine-2-carboxylic acid With oxalyl dichloride in dichloromethane
3 h;
2: azetidine hydrochloride With triethylamine in dichloromethane
0.166667 h;
参考文献
AstraZeneca AB
Patent: US2008/153800 A1, 2008 ;
Location in patent: Page/Page column 6 ;
US 20080153800 A1
