反应条件
1: 1,4-dihydro-2,6-dimethyl-5-methoxy-carbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide in dichloromethane 1 h; Sonographic reactionCooling with ice; 2: 3-hydroxy-N-phenylmethylpiperidine in dichloromethane 2.5 h; Cooling with iceSonographic reaction;
参考文献
HEFEI BEINI MEDICAL TECHNOLOGY COMPANY, LTD; ZHANG, Zhaoyong
Patent: WO2012/142815 A1, 2012 ;
Location in patent: Page/Page column 5; 6 ;