(R)-(-)-1-苄基-3-羟基哌啶合成路线 （共 10 条）
反应条件
sulfuric acid in tetrahydrofuran T=180°C; 16 h; microwave irradiation;
参考文献
Metro, Thomas-Xavier; Pardo, Domingo Gomez; Cossy, Janine
Synlett, 2007 , # 18 p. 2888 - 2890
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 72 h;
参考文献
Skaddan; Kilbourn; Snyder; Sherman; Desmond; Frey
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4552 - 4562
反应条件
phosphate buffer in 1,4-dioxane T=25°C; 74 h; lipase PS;
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
1: methanol / 2 h / Heating 2: toluene / 2 h / 90 °C 3: 47 percent / phosphate buffer (pH 7.0) / dioxane / 74 h / 25 °C / lipase PS View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215
反应条件
IL1-PS lipase in toluene T=20°C; 20 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 13 p. 2321 - 2327
反应条件
1: toluene / 2 h / 90 °C 2: 47 percent / phosphate buffer (pH 7.0) / dioxane / 74 h / 25 °C / lipase PS View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215
反应条件
1: methanol / 2 h / Heating 2: toluene / 2 h / 90 °C 3: 47 percent / phosphate buffer (pH 7.0) / dioxane / 74 h / 25 °C / lipase PS View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215
反应条件
triethylamine in toluene 5 h; Heating; Yield given;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 38, # 11 A p. 1662 - 1665
反应条件
Bacillus licheniformis subtilisin; water T=20°C; 16 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 18 p. 2112 - 2116
反应条件
sodium hydroxide; dichloromethane; triethylamine; trifluoroacetic anhydride 1.) reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 36, # 4 p. 549 - 552
