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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
916069-05-1
合成路线
（共 6 条）
916069-05-1
→
反应条件
77307-50-7
3'',4''-二-O-乙酰基阿福豆苷
反应条件
1.1: 77 percent / OsO4; NMO / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C 2.1: p-TsOH*H2O / CH2Cl2 / 0.25 h / 0 °C 2.2: 99 percent / aq. HOAc / CH2Cl2 / 0.25 h / 0 °C 3.1: 62 percent / DBU / toluene / 1 h / 0 °C 4.1: 91 percent / DBU / toluene / 1 h / 0 °C View Scheme
参考文献
Shan, Mingde; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
247244-65-1
→
反应条件
916069-05-1
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: 60 percent / DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 12 h / -78 °C<br />2: 85 percent / PPh<sub>3</sub> / Pd<sub>2</sub>(dba)3*CHCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 °C<br />3: 73 percent / NaBH<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub>; methanol / 3 h / -78 °C<br />4: 156 mg / pyridine; DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 0 °C<br /> <br />
参考文献
Shan, Mingde; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
4208-64-4
DL-1-(2-呋喃基)乙醇
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反应条件
916069-05-1
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1: 90 percent / NaHCO<sub>3</sub>; NaOAc*3H<sub>2</sub>O; NBS / tetrahydrofuran; H<sub>2</sub>O / 1 h / 0 °C<br />2: 60 percent / DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 12 h / -78 °C<br />3: 85 percent / PPh<sub>3</sub> / Pd<sub>2</sub>(dba)3*CHCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 °C<br />4: 73 percent / NaBH<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub>; methanol / 3 h / -78 °C<br />5: 156 mg / pyridine; DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 0 °C<br /> <br />
参考文献
Shan, Mingde; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
88607-79-8
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反应条件
916069-05-1
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1.1: 76 percent / I<sub>2</sub> / dimethylsulfoxide / 24 h / 110 °C<br />2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH<sub>2</sub>Cl<sub>2</sub> / -20 - 0 °C<br />2.2: 50 percent / TsOH*H<sub>2</sub>O / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 20 °C<br />3.1: 85 percent / PPh<sub>3</sub> / Pd<sub>2</sub>(dba)3*CHCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 °C<br />4.1: 73 percent / NaBH<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub>; methanol / 3 h / -78 °C<br />5.1: 156 mg / pyridine; DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 0 °C<br /> <br />
参考文献
Shan, Mingde; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
1192-62-7
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反应条件
916069-05-1
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1: 92 percent / formic acid; Et<sub>3</sub>N / (R)-Ru(η<sup>6</sup>-mesitylene)-(S,S)-TsDPEN / CH<sub>2</sub>Cl<sub>2</sub> / 24 h / 20 °C<br />2: 90 percent / NaHCO<sub>3</sub>; NaOAc*3H<sub>2</sub>O; NBS / tetrahydrofuran; H<sub>2</sub>O / 1 h / 0 °C<br />3: 60 percent / DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 12 h / -78 °C<br />4: 85 percent / PPh<sub>3</sub> / Pd<sub>2</sub>(dba)3*CHCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 °C<br />5: 73 percent / NaBH<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub>; methanol / 3 h / -78 °C<br />6: 156 mg / pyridine; DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 0 °C<br /> <br />
参考文献
Shan, Mingde; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
100-39-0
→
反应条件
916069-05-1
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1.1: 75 percent / K<sub>2</sub>CO<sub>3</sub> / acetone / 6 h / Heating<br />2.1: 76 percent / I<sub>2</sub> / dimethylsulfoxide / 24 h / 110 °C<br />3.1: DMSO; 3 Angstroem molecular sieves / acetone; CH<sub>2</sub>Cl<sub>2</sub> / -20 - 0 °C<br />3.2: 50 percent / TsOH*H<sub>2</sub>O / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 20 °C<br />4.1: 85 percent / PPh<sub>3</sub> / Pd<sub>2</sub>(dba)3*CHCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 0 °C<br />5.1: 73 percent / NaBH<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub>; methanol / 3 h / -78 °C<br />6.1: 156 mg / pyridine; DMAP / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 0 °C<br /> <br />
参考文献
Shan, Mingde; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
