1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=-78 - 0°C; 3.75 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexane; toluene T=20°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/127587 A1, 2006 ;
Location in patent: Page/Page column 95-96 ;
WO 2006/127587 A1