sodium acetate; potassium bromide; palladium diacetate in various solvent(s) T=90 - 100°C; Heck coupling;

sodium acetate; potassium bromide; palladium diacetate in water T=90°C; Heck reaction;

1.1: lithium diisopropylamide / tetrahydrofuran / -70 °C 1.2: 82 percent / iodine / tetrahydrofuran / -70 °C 2.1: 80 percent / sodium acetate; potassium bromide / palladium(II) acetate / various solvent(s) / 90 - 100 °C View Scheme

1.1: hydrobromic acid; sodium nitrite / H2O 1.2: 97 percent / potassium bromide / H2O 2.1: lithium diisopropylamide / tetrahydrofuran / -70 °C 2.2: 82 percent / iodine / tetrahydrofuran / -70 °C 3.1: 80 percent / sodium acetate; potassium bromide / palladium(II) acetate / various solvent(s) / 90 - 100 °C View Scheme

1: N,N-dimethyl-acetamide 2: sodium acetate; potassium bromide / palladium(II) acetate / various solvent(s); H2O / 90 °C View Scheme

1: 91 percent / tetrabutylammonium bromide; triphenylphosphine; sodium carbonate / palladium(II) acetate; potassium chloride / toluene; H2O / Heating 2: 88 percent / 3-chloroperoxybenzoic acid / toluene / 24 h / 20 °C 3: 85 percent / phosphorus oxychloride View Scheme