4-[4-(4'-氯联苯-2-基甲基)哌嗪-1-基]苯甲酸合成路线 （共 4 条）
反应条件
1: With lithium hydroxide hydrate; water in 1,4-dioxane T=95°C; 2: With hydrogenchloride in water
参考文献
CURIS, INC.
Patent: WO2009/36051 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/036051 A1
反应条件
1: 73 percent / aq. Na2CO3 / PdCl2(PPh3)2 / ethanol; 1,2-dimethoxy-ethane / 4.5 h / 90 °C 2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; H2O / 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 641 - 662
反应条件
1: 89 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 1.25 h 2: 73 percent / aq. Na2CO3 / PdCl2(PPh3)2 / ethanol; 1,2-dimethoxy-ethane / 4.5 h / 90 °C 3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; H2O / 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 641 - 662
反应条件
1: 89 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 1.25 h 2: 73 percent / aq. Na2CO3 / PdCl2(PPh3)2 / ethanol; 1,2-dimethoxy-ethane / 4.5 h / 90 °C 3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; H2O / 16 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 641 - 662
