6-(氨基甲基)-2H-苯并[b][1,4]噁嗪-3(4h)-酮盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 3 h;
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
反应条件
1: 1-methyl-pyrrolidin-2-one / 250 °C / Inert atmosphere
2: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C
3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
反应条件
1: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C
2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
