(9CI)-5,6,6a,7,8,9-六氢吡啶并[3,2-e]吡咯并[1,2-a]吡嗪合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
18 h; Heating;
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: 87 percent / triethylamine / dimethylsulfoxide / 18 h / 60 °C
2: 56 percent / glacial acetic acid, iron powder / 3 h / 60 - 65 °C
3: 65 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: 56 percent / glacial acetic acid, iron powder / 3 h / 60 - 65 °C
2: 65 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
