1-Boc-5-溴-3-碘-1H-吡唑并[3,4-b]吡啶合成路线 （共 3 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/130673 A1, 2006 ;
Location in patent: Page/Page column 86-87 ;
WO 2006/130673 A1
反应条件
1: 90 percent / I2; NaOH / dioxane / 8 h / 40 °C
2: 52 percent / Br2; acetic acid / 12 h / 100 °C
3: 94 percent / DMAP; Et3N / tetrahydrofuran
View Scheme
参考文献
Huang, Shenlin; Lin, Ronghui; Yu, Yang; Lu, Yanhua; Connolly, Peter J.; Chiu, George; Li, Shengjian; Emanuel, Stuart L.; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1243 - 1245
反应条件
1: 52 percent / Br2; acetic acid / 12 h / 100 °C
2: 94 percent / DMAP; Et3N / tetrahydrofuran
View Scheme
参考文献
Huang, Shenlin; Lin, Ronghui; Yu, Yang; Lu, Yanhua; Connolly, Peter J.; Chiu, George; Li, Shengjian; Emanuel, Stuart L.; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1243 - 1245
