4-(氯甲基)苯基氨基甲酸叔丁酯合成路线 (共 2 条)
反应条件
pyridine; thionyl chloride in dichloromethane
0.5 h;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS INC.
Patent: WO2008/127349 A2, 2008 ;
Location in patent: Page/Page column 103 ;
WO 2008/127349 A2
反应条件
1: isobutyl chloroformate / dichloromethane / 0.25 h
2: hydrogenchloride / water / 1 h
View Scheme
参考文献
Nasim, Shama; Guzman, Monica L.; Jordan, Craig T.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4879 - 4883