1: 4-chloro-2-fluoro-1-methoxybenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: carbon dioxide in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
TARGEGEN, INC.
Patent: WO2006/101977 A2, 2006 ;
Location in patent: Page/Page column 110-111 ;
WO 2006/101977 A2