3,5-二甲基吡嗪-2-胺合成路线 （共 3 条）
反应条件
ammonium hydroxide; copper(II) oxide T=150°C; 72 h; Sealed tube;
参考文献
PTC THERAPEUTICS, INC.; CHEN, Guangming; DAKKA, Amal; KARP, Gary Mitchell; LI, Chunshi; NARASIMHAN, Jana; NARYSHKIN, Nikolai; WEETALL, Maria L.; WELCH, Ellen; ZHAO, Xin
Patent: WO2013/112788 A1, 2013 ;
Location in patent: Paragraph 00661 ;
反应条件
1: sulfuryl dichloride / N,N-dimethyl-formamide / 2.5 h / 60 °C / |Cooling with ice 2: copper(II) oxide; ammonium hydroxide / 72 h / 150 °C / |Sealed tube View Scheme
参考文献
Journal of the Chemical Society, , p. 932
