3-(3-(苄氧基)苯基)氮杂丁烷-1-羧酸叔丁酯合成路线 (共 1 条)
反应条件
1: 3-Iodo-azetidine-1-carboxylic acid tert-butyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in N,N-dimethyl-formamide
T=20 - 70°C; 2.16667 h;
2: 3-benzyloxy-iodobenzene With tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in N,N-dimethyl-formamide
T=70°C; 4 h;
参考文献
PFIZER LIMITED
Patent: WO2006/134487 A1, 2006 ;
Location in patent: Page/Page column 41 ;
WO 2006/134487 A1