4-甲基-1-(3-硝基-5-三氟甲基-苯基)-1H-咪唑合成路线 (共 5 条)
反应条件
hydrogen; 5 palladium over charcoal in ethanol T=70°C; P=3000.3 Torr; 3 h; Product distribution / selectivity;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2006/135640 A2, 2006 ;
Location in patent: Page/Page column 23 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=180°C; 0.0833333 h; Microwave irradiation;
参考文献
PHOENIX CHEMICALS LIMITED
Patent: WO2008/38042 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 3,5-Dinitrobenzotrifluoride With potassium carbonate in N,N-dimethylacetamide (DMA)
0.166667 h;
2: 4-methyl-1H-imidazole in N,N-dimethylacetamide (DMA)
T=95°C; 15 - 20 h;
3: With carbon in cyclohexane
Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/135619 A1, 2006 ;
Location in patent: Page/Page column 4; 6 ;
反应条件
1: 4-methyl-1H-imidazole With potassium carbonate in N,N-dimethyl-formamide
T=100°C; 1 h;
2: 1-bromo-3-nitro-5-(trifluoromethyl)benzene in N,N-dimethyl-formamide
T=108°C; 3.16667 h; Product distribution / selectivity;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2006/135640 A2, 2006 ;
Location in patent: Page/Page column 24-25 ;
反应条件
in dimethyl sulfoxide
T=140°C;
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 107 ;
WO 2009/049028 A1