N7-[(2-羟基乙氧基)甲基)鸟嘌呤合成路线 （共 8 条）
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile
T=0 - 25°C; 1 h;
参考文献
Hakimelahi, Gholam Hossein
Patent: US2004/2475 A1, 2004 ;
反应条件
methylamine
T=80°C; 0.5 h;
参考文献
Madre, M. A.; Zhuk, R. A.; Lidak, M. Yu.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 11 p. 806 - 809
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 11 p. 1371 - 1375
反应条件
1: (NH4)2SO4 / 24 h / Heating
2: 3.54 g / acetonitrile / 7 h / 25 °C
3: 88 percent / dimethylformamide / 8 h / 25 °C
4: 82 percent / dimethylformamide / 25 °C
5: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C
View Scheme
参考文献
Hakimelahi; Tai Wei Ly; Moosavi-Movahedi; Jain; Zakerinia; Davari; Mei; Sambaiah; Moshfegh
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3710 - 3720
反应条件
1: 3.54 g / acetonitrile / 7 h / 25 °C
2: 88 percent / dimethylformamide / 8 h / 25 °C
3: 82 percent / dimethylformamide / 25 °C
4: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C
View Scheme
参考文献
Hakimelahi; Tai Wei Ly; Moosavi-Movahedi; Jain; Zakerinia; Davari; Mei; Sambaiah; Moshfegh
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3710 - 3720
反应条件
1: 82 percent / dimethylformamide / 25 °C
2: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C
View Scheme
参考文献
Hakimelahi; Tai Wei Ly; Moosavi-Movahedi; Jain; Zakerinia; Davari; Mei; Sambaiah; Moshfegh
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3710 - 3720
反应条件
1: 88 percent / dimethylformamide / 8 h / 25 °C
2: 82 percent / dimethylformamide / 25 °C
3: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C
View Scheme
参考文献
Hakimelahi; Tai Wei Ly; Moosavi-Movahedi; Jain; Zakerinia; Davari; Mei; Sambaiah; Moshfegh
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3710 - 3720
反应条件
1: 1.) p-toluenesulfonic acid / 1.) AcOH, 2.) toluene, reflux, 16 h
2: 82 percent / aq. MeNH2 / 0.5 h / 80 °C
View Scheme
参考文献
Madre, M. A.; Zhuk, R. A.; Lidak, M. Yu.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 11 p. 806 - 809
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 11 p. 1371 - 1375
反应条件
sodium hydroxide; toluene-4-sulfonic acid
1.) 100 deg C, 20 h, 2.) room temperature, overnight; Yield given. Multistep reaction;
参考文献
Shiragami; Koguchi; Tanaka; Takamatsu; Uchida; Ineyama; Izawa
Nucleosides and Nucleotides, 1995 , vol. 14, # 3-5 p. 337 - 340
