6-溴-1,2-二氢-2,2,4-三甲基喹啉合成路线 （共 7 条）
反应条件
1: 6-bromo-2,2,4-trimethyl-1,2-dihydroquinoline With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 0.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran; hexane T=20 - 25°C; 3 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1844768 A1, 2007 ;
Location in patent: Page/Page column 34 ;
反应条件
palladium diacetate; potassium fluoride; 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran; toluene T=20°C; Suzuki coupling; 16 h;
参考文献
Takahashi, Hidenori; Bekkali, Younes; Capolino, Alison J.; Gilmore, Thomas; Goldrick, Susan E.; Nelson, Richard M.; Terenzio, Donna; Wang, Ji; Zuvela-Jelaska, Ljiljana; Proudfoot, John; Nabozny, Gerald; Thomson, David
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1549 - 1552
反应条件
1: T=25 - 35°C;
2: With ammonium cerium (IV) nitrate
T=50 - 55°C; 24 h;
参考文献
Durgadas, Shylaprasad; Chatare, Vijay K.; Mukkanti, Khagga; Pal, Sarbani
Letters in Organic Chemistry, 2010 , vol. 7, # 4 p. 306 - 310
反应条件
nitrogen in tetrahydrofuran; ethyl acetate
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5696133 A1, 1997 ;
反应条件
in N-(6,7-dibutoxy-4-methyl-2-quinazolinyl)guanidine
参考文献
Forray, Carlos C.; Kawakami, Joel; Konkel, Michael J.; Boteju, Lakmal W.; Wetzel, John M.; Noble, Stewart A.; Wan, Honghe
Patent: US2003/176314 A1, 2003 ;
US 20030176314 A1
反应条件
potassium dodecatangestocobaltate trihydrate
Skraup reaction; 0.333333 h; microwave irradiation;
参考文献
Bose, D. Subhas; Kumar, Racherla Kishore
Heterocycles, 2006 , vol. 68, # 3 p. 549 - 559
反应条件
[MoO2Cl2(dmf)2]
T=110°C; 48 h; Neat (no solvent);
参考文献
Garcia, Nuria; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Rubio, Ruben; Pedrosa, Maria R.; Arnaiz, Francisco J.; Sanz, Roberto
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 321 - 327
