3-氟-4-(2-羟基乙氧基)苯甲腈合成路线 （共 3 条）
反应条件
1: ethylene glycol With potassium tert-butylate
T=50°C;
2: 3,4-difluorobenzylnitrile T=20 - 80°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/135316 A1, 2006 ;
Location in patent: Page/Page column 67 ;
WO 2006/135316 A1
反应条件
1: ethylene glycol With potassium tert-butylate
T=50°C;
2: 3,4-difluorobenzylnitrile in ethylene glycol
T=50 - 80°C; 2 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/137770 A1, 2006 ;
Location in patent: Page/Page column 35 ;
WO 2006/137770 A1
反应条件
1: 3-fluoro-4-hydroxybenzonitrile With potassium carbonate in acetonitrile
T=20 - 80°C; 1 h;
2: 2-bromo-1-ethanol in acetonitrile
T=80°C; 6.33333 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2006/137770 A1, 2006 ;
Location in patent: Page/Page column 37-38 ;
WO 2006/137770 A1
