1: TBAF / tetrahydrofuran / 0.75 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-40&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 78 percent / hydrazine hydrate; acetic acid; pyridine / 24 h / 20 &deg;C<br />2: 81 percent / pyridine / CH₂Cl₂ / -40 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 50 - 60 &deg;C<br />1.2: 74 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / 65 - 70 &deg;C<br />2.1: 78 percent / hydrazine hydrate; acetic acid; pyridine / 24 h / 20 &deg;C<br />3.1: 81 percent / pyridine / CH₂Cl₂ / -40 &deg;C<br /> <br /> &nbsp;