1.1: 85 percent / TBAF / tetrahydrofuran / 2 h 2.1: K2CO3 / methanol / 2 h 2.2: 75 percent / acetone / 12 h View Scheme

<b>Multi-step reaction with 6 steps<br /> </b>1: 90 percent / Ph₃P; K₂CO₃ / Pd/C; CuI / H₂O; 1,2-dimethoxy-ethane / 2 h / 80 &deg;C<br />2: 90 percent / Pd/C / ethyl acetate<br />3: 95 percent / imidazole; DMAP / CH₂Cl₂ / 2 h<br />4: 90 percent / PPTS / methanol / 12 h<br />5: 90 percent / IBX; DMSO / CH₂Cl₂ / 2 h<br />6: 80 percent / SnCl₂ / CH₂Cl₂ / 0.67 h / 0 - 20 &deg;C<br /> <br /> &nbsp;