4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲酯合成路线 （共 9 条）
反应条件
sodium hydroxide in butan-1-ol 12 h; Heating / reflux;
参考文献
WO2008/137605 A1, ;
Page/Page column 25; 26 ;
WO 2008/137605 A1
反应条件
copper(l) iodide; potassium carbonate in 1,4-dioxane T=20 - 120°C; Sealed tubeInert atmosphere;
参考文献
Kalesh, Karunakaran A.; Liu, Kai; Yao, Shao Q.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5129 - 5136
反应条件
C43H63ClNO2PPd; caesium carbonate in 1,4-dioxane T=120°C; 1.5 h; Inert atmosphere;
参考文献
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 700 - 706
反应条件
1: With sodium hydroxide; ethanol 16 h; Heating / reflux; 2: With hydrogenchloride; water pH=~ 3 - 4;
参考文献
US2008/300268 A1, ;
Page/Page column 59-60 ;
反应条件
1: toluene / 18 h / Inert atmosphere; Reflux 2: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 3: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706
反应条件
1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 2: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706
反应条件
potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 12 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706
反应条件
1: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere 2: 3,4,5,6-tetramethyl-t-Bu-X-Phos; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706
反应条件
water; lithium hydroxide hydrate in methanol T=20°C; 8 h;
参考文献
Kalesh, Karunakaran A.; Liu, Kai; Yao, Shao Q.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5129 - 5136
