2-(4-硝基苯基)-1,3-丙烷二醇合成路线 （共 9 条）
反应条件
diisobutylaluminium hydride in diethyl ether
T=-78 - 20°C;
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
sodium tetrahydroborate; bromine in ethylene glycol dimethyl ether
T=0 - 20°C; 4 h;
参考文献
Tudge, Matthew; Mashima, Hiroko; Savarin, Cecile; Humphrey, Guy; Davies, Ian
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 1041 - 1044
反应条件
1.1: (COCl)2; DMF / tetrahydrofuran / 0.17 h
2.1: LDA / tetrahydrofuran / 1 h / -78 °C
2.2: 78 percent / tetrahydrofuran / -78 - 20 °C
3.1: 65 percent / DIBAH / diethyl ether / -78 - 20 °C
View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: 78 percent / tetrahydrofuran / -78 - 20 °C
2.1: 65 percent / DIBAH / diethyl ether / -78 - 20 °C
View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: 78 percent / tetrahydrofuran / -78 - 20 °C
2.1: 65 percent / DIBAH / diethyl ether / -78 - 20 °C
View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
tetraethylammonium p-toluenesulfonate in N,N-dimethyl-formamide
3.6 h; Ambient temperatureelectroreduction;
参考文献
Torii, Sigeru; Murakami, Yasuo; Tanaka, Hideo; Okamoto, Koichi
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3143 - 3147
反应条件
1: 93 percent / Et3N; DMAP / CH2Cl2 / 3 h / 0 - 20 °C
2: ammonium nitrate; trifluoroacetic anhydride / CHCl3 / 0 - 20 °C
3: aq. NaOH / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Hu, Jian; Mattern, Daniell Lewis
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2277 - 2281
反应条件
sodium hydroxide in ethanol
Deacetylation; 24 h; Heating;
参考文献
Hu, Jian; Mattern, Daniell Lewis
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2277 - 2281
反应条件
1: ammonium nitrate; trifluoroacetic anhydride / CHCl3 / 0 - 20 °C
2: aq. NaOH / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Hu, Jian; Mattern, Daniell Lewis
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2277 - 2281
