二甲基-2-(4-(甲基磺酰)-2-硝基苯基)丙二酸合成路线 (共 1 条)
反应条件
1: malonic acid dimethyl ester With potassium tert-butylate in tert-butyl alcohol
2: 4-methylsulfonyl-2-nitrochlorobenzene in tert-butyl alcohol
T=20°C; 15 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 91 ;
US 20080009465 A1