(S)-4-苄基-3-氯甲基吗啉合成路线 （共 4 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane
2.5 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2006/137791 A1, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/137791 A1
反应条件
1.1: potassium carbonate / water; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 6 h / 20 °C
2.2: 2 h / 80 °C
3.1: thionyl chloride / dichloromethane / 15 h
View Scheme
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; MARUYAMA, Megumi; KINOMURA, Naoya; NOJIMA, Satoshi; TAKAMURA, Masahiro; KAKIGUCHI, Keisuke; TATAMITANI, Hiroto
Patent: WO2011/111875 A1, 2011 ;
WO 2011/111875 A1
反应条件
1.1: borane-THF / tetrahydrofuran / 6 h / 20 °C
1.2: 2 h / 80 °C
2.1: thionyl chloride / dichloromethane / 15 h
View Scheme
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; MARUYAMA, Megumi; KINOMURA, Naoya; NOJIMA, Satoshi; TAKAMURA, Masahiro; KAKIGUCHI, Keisuke; TATAMITANI, Hiroto
Patent: WO2011/111875 A1, 2011 ;
WO 2011/111875 A1
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; water
20 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2006/137790 A1, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/137790 A1
