2-疏基-4,6-二羟基-嘧啶合成路线 （共 14 条）
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP1247804 A1, 2002 ;
Location in patent: Page 12 ;
反应条件
tetra(n-butyl)ammonium hydroxide
1.) water, 10 min, 2.) MeOH, reflux, 8 h; Yield given. Multistep reaction;
参考文献
Seto, Shigeki; Okada, Kyoko; Kiyota, Koichi; Isogai, Shigeki; Iwago, Maki; Shinozaki, Takehiro; Kitamura, Yoshiaki; Kohno, Yasushi; Murakami, Koji
Journal of Medicinal Chemistry, 2010 , vol. 53, # 13 p. 5012 - 5024
反应条件
1: 2-mercapto-4,6-dihydroxy-pyrimidine With sodium hydroxide in ethanol; water
T=20°C; Reflux;
2: 1-bromo-octane in ethanol; water
T=20°C; Reflux;
参考文献
Seto, Shigeki; Okada, Kyoko; Kiyota, Koichi; Isogai, Shigeki; Iwago, Maki; Shinozaki, Takehiro; Kitamura, Yoshiaki; Kohno, Yasushi; Murakami, Koji
Journal of Medicinal Chemistry, 2010 , vol. 53, # 13 p. 5012 - 5024
参考文献
Mao, Yongjun; Tian, Wang; Huang, Ziwei; An, Jing
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 594 - 597
