(S)-4-(2-吡咯烷基甲基)吗啉合成路线 （共 9 条）
参考文献
Luzzio, Michael Joseph; Yang, Bingwei Vera; Marx, Matthew Arnold
Patent: US2002/42409 A1, 2002 ;
反应条件
lithium in tetrahydrofuran; ethanol; ammonia
0.25 h; Heating;
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
1: H2 / 5percent Pd/C / methanol
2: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
1: 73 percent / DCC / CH2Cl2 / 0 deg C to r.t.
2: H2 / 5percent Pd/C / methanol
3: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
1: 65 percent / triethylamine / CH2Cl2 / 24 h / Heating
2: 74 percent / DBU / toluene / 24 h / Heating
3: 75 percent / lithium / tetrahydrofuran; ethanol; liquid ammonia / 0.25 h / Heating
View Scheme
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
1: 74 percent / DBU / toluene / 24 h / Heating
2: 75 percent / lithium / tetrahydrofuran; ethanol; liquid ammonia / 0.25 h / Heating
View Scheme
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
1: 78 percent / NaIO4, RuO2 / H2O; ethyl acetate / 0.5 h / 0 °C
2: 1.) trifluoroacetic acid (TFA), 2.) 2 M aq. NaOH / 1.) CHCl3, reflux, 24 h, 2.) 90 deg C, 1 h
View Scheme
参考文献
Alker; Doyle; Harwood; McGregor
Tetrahedron Asymmetry, 1990 , vol. 1, # 12 p. 877 - 880
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
20 h; Heating; Yield given;
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
反应条件
sodium hydroxide; trifluoroacetic acid
1.) CHCl3, reflux, 24 h, 2.) 90 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Alker; Doyle; Harwood; McGregor
Tetrahedron Asymmetry, 1990 , vol. 1, # 12 p. 877 - 880
