3-(4-哌啶基甲氧基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
2.2: 16 h / 50 °C
3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.
Patent: WO2011/31628 A1, 2011 ;
WO 2011/031628 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
1.2: 16 h / 50 °C
2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.
Patent: WO2011/31628 A1, 2011 ;
WO 2011/031628 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
1.2: 16 h / 50 °C
2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; TING, Pauline, C.; ASLANIAN, Robert; CAO, Jianhua; KIM, David; ZORN, Nicolas
Patent: WO2012/24179 A1, 2012 ;
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran
4.5 h;
2: With sodium hydroxide; water
参考文献
Apodaca, Richard; Barbier, Ann J.; Carruthers, Nicholas I.; Gomez, Leslie A.; Keith, John M.; Lovenberg, Timothy W.; Wolin, Ronald L.
Patent: US2006/293316 A1, 2006 ;
Location in patent: Page/Page column 36 ;
US 20060293316 A1
