4-氨基-3-乙氧基苯甲酰胺合成路线 （共 4 条）
反应条件
ammonium formate; 5 Pd(II)/C(eggshell) in methanol
T=20°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; AUSTEN, Matthias; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; SCHREITER, Kay; SCHNEIDER, Martin
Patent: WO2010/23181 A1, 2010 ;
Location in patent: Page/Page column 50-51 ;
WO 2010/023181 A1
反应条件
1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice
2: ammonium formate / palladium on activated charcoal / methanol / 2 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; AUSTEN, Matthias; SCHNEIDER, Martin; SCHREITER, Kay
Patent: WO2011/104338 A1, 2011 ;
WO 2011/104338 A1
反应条件
1: potassium carbonate / water; acetone / 20 °C
2: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice
3: ammonium formate / palladium on activated charcoal / methanol / 2 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; AUSTEN, Matthias; SCHNEIDER, Martin; SCHREITER, Kay
Patent: WO2011/104338 A1, 2011 ;
WO 2011/104338 A1
反应条件
toluene-4-sulfonic acid in isopropyl alcohol
T=100°C; 20 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; AUSTEN, Matthias; SCHNEIDER, Martin; SCHREITER, Kay
Patent: WO2011/104338 A1, 2011 ;
Location in patent: Page/Page column 64-65 ;
WO 2011/104338 A1
