1: With thionyl chloride; N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 1.5 h; 2: With ammonia; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; 1,4-dioxane T=0 - 50°C; 83 h;

1: methanol With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: 2,5-difluoro-4-nitrobenzamide in tetrahydrofuran T=0 - 20°C; 18 h;