1: NaOH / methanol; H2O / 0.5 h / sonication 2: triethylamine / CH2Cl2 / 0.33 h 3: crown ether / dimethylformamide / 66 h 4: NaOH / methanol; H2O / sonication 5: 99 percent / triethylamine; DMAP / CH2Cl2 / 0.5 h / 20 °C 6: 98 percent / sodium azide; 1,4-diaza-bicyclo[2.2.2]octane; 4-dimethylaminopyridine / benzo-15-crown-5 / CH2Cl2 / 20 h / 40 °C 7: 99 percent / hydrogen / Pd/C / methanol / 2 h 8: aq. HCl / 20 h / Heating 9: NaOH; NaHCO3 / H2O / 63 h 10: 74 mg / hydrogen / Pd/C / methanol / 2 h View Scheme

1: NaOH / methanol; H2O / 0.5 h / sonication 2: triethylamine / CH2Cl2 / 0.33 h 3: crown ether / dimethylformamide / 66 h 4: NaOH / methanol; H2O / sonication 5: 99 percent / triethylamine; DMAP / CH2Cl2 / 0.5 h / 20 °C 6: 98 percent / sodium azide; 1,4-diaza-bicyclo[2.2.2]octane; 4-dimethylaminopyridine / benzo-15-crown-5 / CH2Cl2 / 20 h / 40 °C 7: 99 percent / hydrogen / Pd/C / methanol / 2 h 8: aq. HCl / 20 h / Heating 9: NaOH; NaHCO3 / H2O / 63 h View Scheme