1: With ammonia in 1-methyl-pyrrolidin-2-one; water
T=80 - 90°C; P=300.03 Torr; 3.25 h; in sealed reactor;
2: With acetic acid in 1-methyl-pyrrolidin-2-one; water
pH=6;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2157 A2, 2007 ;
Location in patent: Page/Page column 75 ;
WO 2007/002157 A2