1: 94 percent / LiOH / methanol / 12 h / 4 °C 2: 78 percent / trifluoroacetic acid / CH2Cl2 / 20 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11324583', constants.ctx, '0')">1,1'-bis-(diphenylphosphino)ferrocene</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11324029', constants.ctx, '0')">tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=40&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / Et₃N / tetrahydrofuran / 2 h / 0 - 20 &deg;C<br />2: 82 percent / 1,1'-bis(diphenylphosphino)ferrocene; Et₃N / Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 4 h / 40 &deg;C<br /> <br /> &nbsp;