5-溴-3-碘-1-[2-(三甲基锡)乙氧基甲基]-1H-吲唑合成路线 （共 4 条）
反应条件
1: With sodium hydride in tetrahydrofuran
T=0°C;
2: With trimethylsilyl ethoxymethyl chloride in tetrahydrofuran
T=0 - 20°C;
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Rault, Sylvain
Synthesis, 2006 , # 20 p. 3506 - 3514
反应条件
1: 94 percent / I2; KOH / dimethylformamide / 1 h / 20 °C
2: 99 percent / aq. KOH; tetrabutylammonium bromide / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Rault, Sylvain
Synthesis, 2006 , # 20 p. 3506 - 3514
反应条件
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0 °C
2.2: 0 - 20 °C
View Scheme
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
