4-氯-3-醛基-7-氮杂吲哚合成路线 (共 2 条)
反应条件
1: 3-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 25°C; 2 h; 3: With water; ammonium chloride more than 3 stages;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12635 A2, 2008 ;
Location in patent: Page/Page column 90 ;
反应条件
acetic acid in water 14 h; Heating / reflux;
参考文献
WO2009/23623 A1, ;
Page/Page column 70 ;
WO 2009/023623 A1