bis-triphenylphosphine-palladium(II) chloride; potassium carbonate in ethylene glycol dimethyl ether T=130°C; Suzuki coupling; 0.5 h; Inert atmosphereMicrowave irradiation;

potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=20 - 120°C; 2 h; Product distribution / selectivity;

hydrogenchloride in water T=50°C; 1 h; Inert atmosphere; Product distribution / selectivity;

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme

1: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 2: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 3: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme

1: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C 2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme

1: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 2: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme

quinoline; Cr2Cu2O5 T=220°C; 0.2 h; Microwave irradiation;

1: lithium hydroxide hydrate / tetrahydrofuran 2: quinoline; Cr2Cu2O5 / 0.2 h / 220 °C / |Microwave irradiation View Scheme