4-氯-3-硝基-1H-吡咯并[2,3-B]吡啶合成路线 （共 2 条）
反应条件
sulfuric acid; nitric acid T=0 - 10°C; 0.5 h;
参考文献
GENENTECH, INC.; HAN, Chong
Patent: WO2013/163109 A1, 2013 ;
Location in patent: Paragraph 00118 ;
反应条件
1: With methanesulfonyl chloride in N,N-dimethyl-formamide T=65°C; 2 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=~ 6.5;
参考文献
WO2007/7919 A2, ;
Page/Page column 43-44 ;
WO 2007/007919 A2
