3-氨基-6-氯-2-氟苯甲酸苄酯合成路线 （共 3 条）
反应条件
1: 4-chloro-2-fluoro-aniline With n-butyllithium in tetrahydrofuran; hexane
Cooling with acetone-dry iceInert atmosphere;
2: With 1,2-bis-(chlorodimethylsilyl)ethane in tetrahydrofuran; hexane
3: benzyl chloroformate
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; WU, Guoxian
Patent: WO2010/129567 A1, 2010 ;
Location in patent: Page/Page column 82-83 ;
反应条件
1: 4-chloro-2-fluoro-aniline With n-butyllithium in tetrahydrofuran; hexane
Inert atmosphereCooling with acetone-dry ice;
2: 1,2-bis-(chlorodimethylsilyl)ethane in tetrahydrofuran; hexane
3: benzyl chloroformate
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha N.; SPEVAK, Wayne; CHO, Hanna; ZHU, Hongyao
Patent: WO2010/104945 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1.1: triethylamine / dichloromethane / 0 - 20 °C
2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / Reflux
2.2: pH 2
3.1: hydrogen / 20 palladium(II) hydroxide on carbon / water; methanol / 3 h
View Scheme
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; RUDOLPH, Joachim; REN, Li
Patent: WO2011/25951 A1, 2011 ;
WO 2011/025951 A1
