(2,4-二氟-3-甲酰基-苯基)-氨基甲酸苄酯合成路线 （共 3 条）
反应条件
1: (2,4-Difluoro-phenyl)-carbamic Acid Benzyl Ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78 - -70°C;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
pH=1;
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha N.; SPEVAK, Wayne; CHO, Hanna; ZHU, Hongyao
Patent: WO2010/104945 A1, 2010 ;
Location in patent: Page/Page column 42 ;
反应条件
1.1: pyridine / dichloromethane / 1.5 h / 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 20 °C
View Scheme
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; ZHANG, Chao; ZHANG, Ying
Patent: WO2011/63159 A1, 2011 ;
反应条件
1.1: pyridine / dichloromethane / 1.5 h / 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 20 °C
View Scheme
参考文献
PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; ZHANG, Chao; ZHANG, Ying
Patent: WO2011/63159 A1, 2011 ;
