吡咯并[2,1-f][1,2,4]三嗪-2,4(1H,3H)-二酮合成路线 （共 6 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=125°C; 24 h; 2: With water; sodium hydrogencarbonate in toluene 0.166667 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080009497 A1
反应条件
1: With pyridine in 1,4-dioxane
T=20°C; 1 h; Heating / reflux;
2: T=155°C; 17 h; Neat (no solvent);
参考文献
Bristol-Myers Squibb Company
Patent: US2007/4731 A1, 2007 ;
Location in patent: Page/Page column 15 ;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
Location in patent: Page/Page column 17-18 ;
US 20080009497 A1
反应条件
1: pyridine / 1,4-dioxane / 1 h / Heating / reflux
2: 17 h / 155 °C
View Scheme
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
US 20080009497 A1
反应条件
1.1: potassium hydroxide; water / 20 °C
2.1: pyridine / 1,4-dioxane / 0.25 h
2.2: 1 h / |Reflux
3.1: sodium ethanolate / ethanol / 2 h / |Reflux
View Scheme
参考文献
Xin, Minhang; Zhang, Liandi; Tang, Feng; Tu, Chongxing; Wen, Jun; Zhao, Xinge; Liu, Zhaoyu; Cheng, Lingfei; Shen, Han
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1429 - 1440
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: 20 °C
2.1: potassium hydroxide; water / 20 °C
3.1: pyridine / 1,4-dioxane / 0.25 h
3.2: 1 h / |Reflux
4.1: sodium ethanolate / ethanol / 2 h / |Reflux
View Scheme
参考文献
Xin, Minhang; Zhang, Liandi; Tang, Feng; Tu, Chongxing; Wen, Jun; Zhao, Xinge; Liu, Zhaoyu; Cheng, Lingfei; Shen, Han
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1429 - 1440
