1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=125°C; 24 h; 2: With water; sodium hydrogencarbonate in toluene 0.166667 h;

1: 17 h / 155 °C 2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 24 h / 125 °C View Scheme

1: pyridine / 1,4-dioxane / 1 h / Heating / reflux 2: 17 h / 155 °C 3: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 24 h / 125 °C View Scheme

1.1: potassium hydroxide; water / 20 °C 2.1: pyridine / 1,4-dioxane / 0.25 h 2.2: 1 h / |Reflux 3.1: sodium ethanolate / ethanol / 2 h / |Reflux 4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 20 °C 2.1: potassium hydroxide; water / 20 °C 3.1: pyridine / 1,4-dioxane / 0.25 h 3.2: 1 h / |Reflux 4.1: sodium ethanolate / ethanol / 2 h / |Reflux 5.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C View Scheme

N-bromosuccinmide in acetonitrile T=0 - 20°C; 17 h;