4-氨基-3,5-二氟吡啶n-氧化物合成路线 （共 4 条）
反应条件
peracetic acid in chloroform
T=20°C; 48 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.
Patent: US2009/306082 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
ammonia in water; acetonitrile
T=70°C; 3 h;
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
1: 71 percent / H2SO4, HNO3 / 5 h / 100 °C
2: 30 percent / NH3 / acetonitrile; H2O / 3 h / 70 °C
View Scheme
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
1: 96 percent / peracetic acid / CHCl3; acetic acid / 67 h / 50 °C
2: 71 percent / H2SO4, HNO3 / 5 h / 100 °C
3: 30 percent / NH3 / acetonitrile; H2O / 3 h / 70 °C
View Scheme
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
