1,1'-[[2-(2-甲氧基苯氧基)乙基]亚氨基]二[3-(9H-咔唑-4-基氧基)-2-丙醇]合成路线 （共 10 条）
反应条件
sodium hydroxide in water; isopropyl alcohol T=50 - 70°C; 0.75 h;
参考文献
CADILA HEALTHCAR LIMITED
Patent: WO2005/80329 A2, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
in dimethyl sulfoxide T=68 - 72°C; 18 - 20 h;
参考文献
IPCA Laboratories Limited
Patent: EP1741700 A1, 2007 ;
Location in patent: Page/Page column 2-3; 6 ;
反应条件
1: 2-(2-methoxy-phenoxy)ethylamine; 4-(oxiran-2-ylmethoxy)-9H-carbazole in isopropyl alcohol T=70 - 85°C; 1 h; Heating / reflux; 2: salicylic acid in isopropyl alcohol T=50 - 85°C; 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
CADILA HEALTHCAR LIMITED
Patent: WO2005/80329 A2, 2005 ;
Location in patent: Page/Page column 6-7 ;
反应条件
in ethylene glycol dimethyl ether T=65°C; 5 h;
参考文献
Rao, Somisetti Narender; Sitaramaiah, Devarasetty; Srimannarayana, Kema; Rao, Challa Nageswar; Rao, Peddi Srinivasa; Babu, K. Sudhakar
Synthetic Communications, 2011 , vol. 41, # 1 p. 85 - 93
反应条件
1: sodium hydroxide / water; dimethyl sulfoxide / 12 h / 25 - 45 °C 2: ethylene glycol dimethyl ether / 5 h / 65 °C View Scheme
参考文献
Synthetic Communications, , vol. 41, # 1 p. 85 - 93
反应条件
sodium hydroxide in water; isopropyl alcohol
T=50 - 70°C; 0.75 h;
参考文献
CADILA HEALTHCAR LIMITED
Patent: WO2005/80329 A2, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
in dimethyl sulfoxide
T=68 - 72°C; 18 - 20 h;
参考文献
IPCA Laboratories Limited
Patent: EP1741700 A1, 2007 ;
Location in patent: Page/Page column 2-3; 6 ;
反应条件
1: 2-(2-methoxy-phenoxy)ethylamine; 4-(oxiran-2-ylmethoxy)-9H-carbazole in isopropyl alcohol
T=70 - 85°C; 1 h; Heating / reflux;
2: salicylic acid in isopropyl alcohol
T=50 - 85°C; 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
CADILA HEALTHCAR LIMITED
Patent: WO2005/80329 A2, 2005 ;
Location in patent: Page/Page column 6-7 ;
反应条件
in ethylene glycol dimethyl ether
T=65°C; 5 h;
参考文献
Rao, Somisetti Narender; Sitaramaiah, Devarasetty; Srimannarayana, Kema; Rao, Challa Nageswar; Rao, Peddi Srinivasa; Babu, K. Sudhakar
Synthetic Communications, 2011 , vol. 41, # 1 p. 85 - 93
反应条件
1: sodium hydroxide / water; dimethyl sulfoxide / 12 h / 25 - 45 °C
2: ethylene glycol dimethyl ether / 5 h / 65 °C
View Scheme
参考文献
Rao, Somisetti Narender; Sitaramaiah, Devarasetty; Srimannarayana, Kema; Rao, Challa Nageswar; Rao, Peddi Srinivasa; Babu, K. Sudhakar
Synthetic Communications, 2011 , vol. 41, # 1 p. 85 - 93
