4-氯-1-乙基-[1,2,4]噻唑并[4,3-a]喹噁啉合成路线 （共 5 条）
参考文献
Warner-Lambert Company
Patent: US4780464 A1, 1988 ;
US 4780464 A
反应条件
in N,N-dimethyl-formamide 20 h; Ambient temperature;
参考文献
Trivedi; Bruns
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1011 - 1014
参考文献
Sarges, Reinhard; Howard, Harry R.; Browne, Ronald G.; Lebel, Lorraine A.; Seymour, Patricia A.; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2240 - 2254
反应条件
1: NH2NH2*H2O / ethanol / Ambient temperature
2: 3 h / 100 °C
View Scheme
参考文献
Trivedi; Bruns
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1011 - 1014
反应条件
ammonia in N,N-dimethyl-formamide
T=25°C; 18 h;
参考文献
Sarges, Reinhard; Howard, Harry R.; Browne, Ronald G.; Lebel, Lorraine A.; Seymour, Patricia A.; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2240 - 2254
