1: N-(carbobenzyloxy)-3-fluoroaniline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.75 h; 2: (S)-(+)-butyric acid oxiranylmethyl ester in tetrahydrofuran; hexane T=-78 - 20°C;

1.1: NaHCO3 / acetone; H2O / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C View Scheme