1: With methanol; sodium hydroxide; water in tetrahydrofuran
1 h; Heating / reflux;
2: With hydrogenchloride; water in dichloromethane; isopropyl alcohol
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/5503 A1, 2007 ;
Location in patent: Page/Page column 36 ;
WO 2007/005503 A1
