4-氯-2-甲基硫代-5-嘧啶合成路线 （共 2 条）
反应条件
1: 2,4-dichloro-5-trifluoromethyl-pyrimidine With zinc(II) chloride in tetrahydrofuran; diethyl ether
2 h; Cooling with iceInert atmosphere;
2: sodium thiomethoxide in tetrahydrofuran; diethyl ether
T=20°C;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 61 ;
反应条件
in tetrahydrofuran
T=-25 - 20°C; 1 h;
参考文献
Zahn, Stephan Karl; Boehmelt, Guido; Mantoulidis, Andreas; Reiser, Ulrich; Treu, Matthias; Guertler, Ulrich; Schoop, Andreas; Solca, Flavio; Tontsch-Grunt, Ulrike; Brueckner, Ralph; Reither, Charlotte; Herfurth, Lars; Kraemer, Oliver; Stadtmueller, Heinz; Engelhardt, Harald
Patent: US2007/32514 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
US 20070032514 A1
