1: 86 percent / 5percent CH3COOH / tetrahydrofuran / 16 h 2: 90 percent / LDA / tetrahydrofuran / -78 °C 3: H2O, 10percent HCl / acetonitrile / 6 h / 50 °C View Scheme

1: 86 percent / 5percent CH3COOH / tetrahydrofuran / 16 h 2: 95 percent / LDA / tetrahydrofuran / -78 °C 3: 63 percent / H2O, 10percent HCl / acetonitrile / 6 h / 50 °C 4: hydrure de lithium aluminium / diethyl ether / 1.5 h / Ambient temperature View Scheme