1: 2-acetyl-octanoic acid ethyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0°C; 0.166667 h; 2: N-capryloyl-2-methyl aziridine in tetrahydrofuran; hexane T=0°C; 3 h;

1.1: potassium hydroxide / ethanol / 2 h / 20 °C 1.2: tartaric acid / H2O; CH2Cl2 / 0.17 h / 0 °C 2.1: 1.21 g / TFA / various solvent(s) / 2 h / -20 °C View Scheme